Best League of Legends Predictions, Odds and Parlays of the Day: April 5th, 2025

Today marks the return of top-tier League of Legends to North America with the start of the 2025 LTA North Split 2. This fierce opening day will see the league's elite go toe-to-toe in exciting matches that might hint at which teams look poised to take the trophy this time around.

Our analyst team has sat down and collected what we think are the best odds and parlays for YOU to predict on today. The outcomes selected are for the best predictions to bet your money on using GGBet.

*Best esports predictions, odds, and parlays for the 5th of April 2025, as collected by the Strafe Esports Content Team.

Match 1: Team Liquid vs FlyQuest

Match Winner - FlyQuest @ 1.69

Team Liquid's rough showing at First Stand 2025 might have tanked the team's confidence heading into Split 2. FlyQuest already took down TL the last time the two teams met, and we expect a similar result this time around in what should be a exciting match between two of the best teams in the LTA.

Though the matchup should be close, our voters lean towards FlyQuest with 52% of the Strafe fan votes picking the team to win.

Race to 3 Kills - FlyQuest @ 1.8

If you're expecting FlyQuest to win their opening game of Split 2, then it all starts with a good early game on the way to securing the Feats of Strength against Team Liquid.

Map Duration - Under 31.5 Minutes @ 2

Professional League of Legends games in general are moving at a faster pace now than they were only months ago. That said, these two teams tend to slow the game down the game when things aren't going their way.

Still, an explosive start to Split 2 for either team could easily mean this match will last well under 31.5 minutes, making this a good bet to make.

Match 2: 100 Thieves vs Cloud9

Match Winner - Cloud9 @ 1.62

Cloud9 looked like one of the strongest teams in the LTA before failing to make the Grand Finals. Now, with more experience playing as a 5-man unit, the historic organization should be able to dispose of the young and unpredictable 100 Thieves if they want to cement themselves as the team to beat.

An overwhelming 76% of the Strafe fan votes picked Cloud9 to win the match, showcasing their expected superiority over 100 Thieves.

Race to 3 Kills - Cloud9 @ 1.77

Under Zven's leadership, Cloud9's decision-making looks much improved in this 2025 season. Though 100 Thieves' early game is impressive in its own right, expect Cloud9 to clean up their act and make little mistakes early on, leading to securing 3 kills faster than their opponents.

Map Duration - Under 30.5 Minutes @ 2.35

These two teams should head out there and play a bloody and fast-paced game that might snowball out of control before you know it.

Best Multi-Bet Parlays

Moderate Risk Parlay:

• FlyQuest win outright (Odds: 1.69).
• Cloud9 to win outright (Odds: 1.62).
• Combination bet odds: 2.73

High Risk, High Reward Parlay:

• FlyQuest to win in under 31.5 minutes (Odds: 3.39).
• Cloud9 to win in under 30.5 minutes (Odds: 3.78).
• Combination bet odds: 12.81

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Feature image credit: Colin Young-Wolff/Riot Games